We have at the moment two different projects where there is a possibility to do a project/thesis. Our group is investigating the function and importance of the alarmin/DAMP HMGB1 in innate immunity but also in juvenile ideopathic arthritis.
In the first project, we aim to characterize a protein-protein interaction and to explore its function in inflammation and possibly cancer or in juvenile ideopathic arthritis.
The second project aims to investigate the impact of HMGB1's tertiary structure on receptor interaction and signaling. We also aim to explore how it affect its extracellular function in an inflammatory context.
Methods that could be included: Cell culture, molecular cloning, qPCR, western blot, analysis of patient samples, ELISA, knockdown cells etc.
Hope to hear from you and don't hesitate to contact me if you have any questions!