Research Scientist in Computational Biology at Celgene

Expires in 4 days

SEVILLA, Spain Req #: 1804289
Location: SEVILLA, Spain
Job Category: Research and Early Development
Work Location: Calla Americo Vespucio 41092
Organization: Computational Biology
Employee Status: Full-time
Job Type: Fixed_Term
Informatics & Predictive sciences is a global team of computational scientists. We pursue innovative computational research towards Celgene objectives, across domains ranging from bioinformatics, computational biology to machine learning, systems biology and mathematical modeling.
(Please note: To apply for this role, you must supply both a CV and a cover letter, outlining your motivations / suitability / background)
Current areas of investigation include application and development of novel computational approaches to unravel the mechanism of action of Celgene’s pipeline compounds, methods for integrative analysis of omics data, predictive approaches to patient stratification, and mathematical models of intra- and inter-cellular processes. In addition, we are involved in a range of academic collaborations aimed at understanding disease at molecular and systems level.
To join our team at the Celgene Institute for Translational Research Europe (CITRE) in Seville, Spain, we are looking for a Research Scientist, Computational Biology. The successful candidate will work closely with Celgene’s global Research Analytics and Drug Discovery and Early Pipeline Biology teams to advance our research and development of novel therapeutic agents for a broad panel of oncology and hematology diseases.
Responsibilities include, but are not limited to:

  • Performing computational biology analysis for exploration and interpretation of high-throughput data, including (single-cell) NGS and proteomics data
  • Developing and implementing mechanistic inference approaches (including models for the integration of multiple genomic data types and public resources) to provide initial interpretation of compound mechanisms of action and gain insights into disease biology.
  • Contributing to experimental design, planning and prioritization in multi-disciplinary teams
  • Presentation and reporting of methods, results and conclusions to a publishable standard
  • Participating in wider group endeavors concerning the elucidation of disease biology, compound mechanisms of action, drug resistance and prediction of target indications.

  • PhD in computational biology / bioinformatics, statistics, computer science or related fields, from a recognized higher-education establishment
  • Prior experience (3+ years) of analysis, integration and interpretation of high-throughput data including proteomics and/or gene expression data supported by high-quality publications
  • Expertise in statistical programming and data manipulation, using e.g. R/Bioconductor, Matlab, Python, plus good knowledge of contemporary database structures
  • Experience in integrative network biology and analysis of single-cell data is a plus
  • Experience with version control and high-performance computing, including cloud computing and/or big data analytics platforms would be advantageous
  • Scientific curiosity, collaborative spirit and proven ability to contribute beyond personal projects
  • Ability to understand and communicate the output of computational research to multi-disciplinary scientific teams
  • Verbal and written English language fluency. Proficiency in Spanish would be advantageous

The position presents a unique opportunity to experience research in an industry setting and to contribute to helping patients with unmet medical need, while maintaining a link to academic research (publication is encouraged).
The position advertised is fixed-term (24 months) and based 100% in Seville, Spain

About Us

At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients. Our vision as a company is to build a major global biopharmaceutical corporation while focusing on the discovery, the development, and the commercialization of products for the treatment of cancer and other severe, immune, inflammatory conditions.
"At Celgene, we seek to deliver truly innovative and life-changing drugs for our patients."
There are more than 300 clinical trials at major medical centers using compounds from Celgene. Investigational compounds are being studied for patients with incurable hematological and solid tumor cancers, including multiple myeloma, myelodysplastic syndromes, chronic lymphocytic leukemia (CLL), non-Hodgkin’s lymphoma (NHL), triple-negative breast cancer and pancreatic cancer. As committed as we are to clinical accomplishment, we are equally committed to patient support, which is a guiding principle at Celgene. We believe all who can benefit from our discoveries should have the opportunity to do so. Celgene puts patients first with industry-leading programs that provide information, support and access to our innovative therapies.

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